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Reichert (SPR) Instruments
For real-time, label-free analysis of biomolecular
interactions 
The SR7000DC is a powerful, flexible and affordable SPR
instrument for determining biomolecular interactions. It provides real-time,
label-free, simultaneous monitoring of sample and reference channels and is
useful in proteomics, genomics, and antibody studies. Its modular design is
easily configured to do customized research. Fluidic configurations range from
manual to fully automated with an optional autosampler. It is able to do
kinetic studies of small molecules down to 100 Daltons. Temperatures are
programmable, micro or macro flow cells are available for different surface
work, and flow rates can be run fast or slow.
Listed below are some examples of biomolecular
interactions which have been successfully studied using the Reichert SPR
SR7000DC instrument:
- Peptide/protein - protein
- DNA/RNA - protein
- Protein - cell
- Receptor - cells
- Protein - virus/phage
- Carbohydrate - protein
- Carbohydrate - cell
- Liposome - protein
- Artificial materials - biological matter
- Drugs - protein
- Drugs - DNA/RNA
Typical areas of use include:
- Kinetics (on, off, equilibrium), relative affinity,
sequence recognition
- Concentration determination
- Ligand fishing followed by MALDI
characterization
- Drug discovery - detection of small molecules down
to 100 Da
- Epitope screening and mapping
- Method/assay development
- Electrochemistry-SPR
- Surface chemistry and biomaterial assessment
- Artificial materials - biological matter
- Photochemistry
In addition to biomolecular interaction studies, the
Reichert SR7000DC can be used to quantify adsorption and desorption processes
in non-biological systems or to follow the course of solid phase-based chemical
reactions on the chip surface.
Outstanding features of the SR7000DC instrument
include:
- Dual-Channel with real time referencing
- Full reflectivity curve downloadable
- Software is visual and user friendly
- Widest dynamic range: 1.32 - 1.6 (175.000 RU or
17.500 mdeg)
- Extremely sensitive: rms noise: < 0.18 ?RIU (0.11
RU or 0.01 mdeg)
- Excellent baseline stability: Maximum drift 0.6
?RIU/hour (0.38 RU/h or 0.038 mdeg/h)
- Inert against solvents and concentrated acids /
bases
- Wide working temperature range: 5 - 90 °C
- Robust: No moving parts and virtually indestructible
sapphire prism
- More than 50 different sensor chip surfaces
- Minimal assembly time - uses off-the-shelf HPLC
fluidics
- Automation for 24 hours operation using 96- or 384-
well plates
- Retrofit or upgrade components anytime
- Combined with other analysis techniques -
electrochemistry, photochemistry, fluorescence, mass spectrometry, liquid
chromatography
- Minimal maintenance costs
- Compact: Just 40 x 33 cm footprint
The Reichert SPR SR7000DC is designed and manufactured
under quality processes meeting ISO 9001 requirements.
For further information and prices, please
click here.
Please also visit the Reichert Website for further
information:
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